Pepperoni Pizza Grilled Cheese

Pepperoni Pizza Grilled Cheese is stuffed with mozzarella, pepperoni sandwiched between two pieces of buttery garlic toast. It’s a fun twist on a classic.

This is a sponsored conversation written by me on behalf of Sara Lee® Bread. As always, all opinions are 100% my own.

Pizza grilled cheese sandwiches cut in half and stacked on a plate

Pizza + Grilled Cheese

Grilled cheese sandwiches are a staple at our house, especially during winter and spring. They are so quick and easy to make! We’re always making them to go along with soup, or serving them with baked beans and fresh fruit.

Since April is National Grilled Cheese Month (April 12th is National Grilled Cheese Day) I thought it would be fun to share a tasty twist on a classic. This version tastes just like pepperoni pizza stuffed between garlic bread and wow is it good—a family favorite!

I used two slices of thick, soft Sara Lee®Artesano™ Bread – it’s the ORIGINAL artisan-style sliced bread. It happens to be free of high fructose corn syrup, artificial flavors and colors which is always a bonus in this mom’s book.

We love using it for French toast too! It’s also available in Golden Wheat, which includes a touch of honey, olive oil and sea salt!

Sara Lee Artesano bread used for pizza sandwich

How to make a pizza sandwich

Cooking your Pizza Sandwich: Because of all the gooey and delicious ingredients you want to cook this low and slow. That way the bread doesn’t burn before the cheese gets melty in the middle. 

If you’re making just a few, the stove top skillet works well. But if you want to make several I suggest using an electric skillet.

COOK. Take one slice of Artesano Bread and put it into a hot skillet along with some butter. Add a slice of mozzarella cheese, followed by pepperoni and another slice of cheese. Place another piece of Artesano Bread on top, then cook and flip.

SPREAD. Once the cheese looks melty, spread the garlic butter on and cook on both sides for an additional 30 seconds. Remove and enjoy!

Tip: since the pepperoni doesn’t actually cook, you’ll want to place it onto a microwave-safe plate lined with a paper towel and cook it for about 20-25 seconds. This will also help release a lot of the grease. Dab it off and it’s ready to go.

Pepperoni grilled cheese with garlic and seasonings


Change out the cheese: Mozzarella is classic for pizza, but you can easily use other cheeses such as white cheddar, monterey Jack, gruyere. Not only can you change out the cheese, but you can also change the toppings:

  • Olives
  • Peppers
  • Mushrooms
  • Spinach
  • Bacon bits
  • Ham
  • Pineapple
  • Sausage crumbles
A hand breaking a pizza grilled cheese sandwich in half


Keep leftover sandwiches STORED in an airtight container in the fridge. You can also wrap them in plastic wrap and then again with foil, or store them together in a Ziploc and store them in the freezer.

Thaw, if applicable, and REHEAT in the oven or in a skillet.

Pizza grilled cheese sandwiches stacked on a plate

For more pepperoni pizza, try:

Pepperoni Pizza Grilled Cheese recipe

5 from 16 votes
Pepperoni Pizza Grilled Cheese is stuffed with mozzarella, pepperoni sandwiched between two pieces of buttery garlic toast. It's a fun twist on a classic.
Course Main Course
Cuisine American
Prep Time 5 minutes
Cook Time 5 minutes
Total Time 10 minutes
Servings 2
Calories 625 kcal
Author Lil’ Luna


  • 1 tbsp. unsalted butter
  • 4 slices Sara Lee® Artesano™ Bread
  • 4 slices mozzarella cheese, 1/8-inch thick
  • 18 slices pepperoni cooked in microwave for 20 seconds and grease dabbed off

For the garlic butter

  • 3 tbsp. unsalted butter
  • 1/4 tsp. fresh or dried parsley
  • ¼ tsp. Italian seasoning
  • 1/4 tsp. garlic powder
  • 1/8 tsp. salt


  • In a medium skillet set over medium-low heat, add the butter and melt. Place two pieces of toast side by side.
  • To each slice of bread, add a slice of mozzarella, 9 pepperoni, and another slice of mozzarella. Place remaining slices of bread on top.
  • Cook on each side for about 3 minutes or until the cheese is melty.
  • Meanwhile, make the garlic butter. In a small microwave safe bowl, add the butter. Heat until melted. Stir in parsley, Italian seasoning, garlic powder, and salt. 
  • Using a pastry brush, brush on both sides of grilled cheese. Cook on each side for 30 seconds. Remove, sprinkle with parmesan cheese and dip in your favorite marinara, if desired.

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This is a sponsored conversation written by me on behalf of Sara Lee Bread. The opinions and text are all mine.

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About the Author

Natalie Dicks

I'm the food photographer and blogger behind Life Made Simple. I'm passionate about creating from scratch family-friendly recipes ranging from healthy to decadent.

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Recipe Rating


  1. 5 stars
    Delicious idea!! I get tired of plain grilled cheese & this was excellent!! my family asked me to make these again soon!

  2. 5 stars
    This is a delicious twist on the classic grilled cheese. My kids LOVED this recipe! So simple to through together too!


  4. 5 stars
    THis recipe is AMAZING!!!!!! I totally recommend it. The seasoned butter makes the bread taste like garlic bread, and it has the perfect amount of pepperoni. The step where it says to put the pepperoni in the microwave and then dab off the grease is ingenious. It makes it so that the grilled cheese doesn’t get greasy! I always toast both sides of my bread, just to get more of that mouth-watering garlic bread flavor and also so it gets the bread more crispy. I also usually cook the pepperoni in the microwave for 15 seconds instead of 20. That way it still retains some of its moisture and it doesn’t get all dried out. MAKE this recipe!!!!

  5. 5 stars
    I found this recipe before i had surgery so my sister came over and made it for Me. Yum yum! She did change up and started cooking them in the Oven. Melt the butter and spices in the microwaVe then brush it on the break. Make the sandwich place in a preheated 350 oven for 10-15 minutes. I flip it half way through. Also its good with italian sub sandwich meat. Thank you for this one!

  6. 5 stars
    Great! I forgot the Parmesan, and substituted left over spaghetti sauce, but they were still very tasty. Forgiving recipe. Thanks. Quick, easy, tasty, and very filling.

  7. 5 stars
    Well this is about the best thing that’s happened to my favorite grilled cheese sandwich. Who can resist pizza? It’s a genius combo. Thanks for this easy and SO SO yummy recipe! We’ll have it for lunch again.

  8. 5 stars
    This is the ultimate grilled cheese right here! The pepperoni and italian seasoning took it up several notches. Making this again soon!

  9. 5 stars
    What a way to add some great flavor to grilled cheese! My kids were in heaven! They love both so much, so combined as one, they loved it!