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Cheesy Mexican casserole is flavorful and filling, packed with layers of chicken, Spanish rice, and a creamy sauce!

Similar to our Chicken Enchilada Casserole, this Mexican casserole is filled with layers of goodness and perfect for any night of the week.

Top view of a cheesy Mexican casserole in a white dish.

We Love Casseroles!

Casseroles are on repeat for dinner at our house, and if it’s a Mexican Casserole Recipe – even better!

This Mexican casserole happens to be a favorite, filled with our popular Spanish Rice, Homemade Salsa, and Taco Seasoning.

Why we love it:

  • Use up leftovers. This is a perfect dish to use up any leftover Spanish rice or chicken. We love to repurpose leftovers!
  • Great for company! Because it makes a 9×13 pan-full, it can easily feed a crowd. Pair it with some Mexican side dishes to stretch the meal even further.
  • Freezer friendly. This casserole recipe freezes beautifully and is ideal for meal prepping or delivering to friends in need.
Diced chicken, seasoning, and spices measured on a kitchen counter.

Ingredients

  • Mexican rice – Make a fresh batch, cook up a store-bought box, or use leftover Spanish Rice.
  • chicken breasts  or cubed chicken thighs. Replace the chicken with ground turkey or brown ground beef, just omit the added vegetable oil and drain any excess grease.
  • taco seasoning – store-bought packet or 2 tablespoons of Taco Seasoning Mix
  • vegetable oil – or olive oil
  • minced garlic
  • Mexican cheese – or use your favorite combination of Monterey jack cheese, cheddar cheese, Colby Cheese, or Mozzarella cheese.
  • cream of chicken soup
  • green chiles – or use diced jalapeno or poblano peppers for extra spice.
  • salsa – store-bought or your favorite Homemade Salsa.
  • fresh cilantro

Make it Vegetarian

Replace the chicken with an equal amount of black beans or pinto beans and use cream of mushroom soup.

Layer + Enjoy!

  1. PREP. Preheat oven to 350°F and grease 9×13 dish with nonstick cooking spray.
  2. CHICKEN. Add cubed chicken to a large skillet with vegetable oil and cook with taco seasoning and minced garlic cloves.
  3. SOUP MIXTURE. Stir together cream of chicken soup, green chiles, and salsa. 
  4. ASSEMBLE. Layer ½ the rice, ½ the chicken, and ½ the soup and salsa mixture in the baking dish. Add 2 cups of cheese on top. Repeat layers once more ending with the cheese. 
  5. BAKE. Bake for 40 minutes and sprinkle with chopped cilantro.

Topping Ideas

Add any of the following to individual servings of your Mexican casserole:

Close up of a cheesy casserole baked in a white casserole dish.

perfect for freezing!

  • Making ahead of time. Prepare the casserole but do not bake. Keep it covered in the refrigerator for 1-2 days.
  • Freezer meal. Assemble it in a freezer-safe container, do not bake. Allow it to cool a bit before wrapping it tightly with plastic and again with aluminum foil. Label and freeze it for 3-4 months. Thaw overnight in the fridge before baking.
  • STORE. Keep any leftovers in an airtight container in the fridge for 3-4 days. Heat it up in the microwave when you’re ready to eat it.
Top view of a Mexican casserole baked and cheesy.

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5 from 37 votes

Mexican Casserole

By: Lil’ Luna
Cheesy Mexican casserole is flavorful and filling, packed with layers of chicken, Spanish rice, and a creamy sauce!
Servings: 12
Prep: 20 minutes
Cook: 40 minutes
Total: 1 hour

Ingredients 

  • 2 cups Mexican Rice
  • 4 chicken breasts, cubed
  • 1 package taco seasoning
  • 3 tablespoons vegetable oil
  • 1 tablespoon minced garlic
  • 4 cups Mexican cheese
  • 1 (10-ounce) can cream of chicken soup
  • 1 can green chiles
  • cups salsa
  • cilantro
Save This Recipe!
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Instructions 

  • Preheat oven to 350°F and grease 9×13 dish.
  • Add cubed chicken to a large saucepan with vegetable oil and cook with taco seasoning and minced garlic.
  • Combine cream of chicken soup, green chiles, and salsa. 
  • Layer ½ the rice, ½ the chicken, and ½ the soup and salsa mixture in your baking dish. Add 2 cups of cheese on top. Repeat layers once more ending with the cheese. 
  • Bake for 40 minutes and sprinkle with chopped cilantro.

Notes

Making ahead of time. Prepare the casserole but do not bake. Keep it covered in the refrigerator for 1-2 days.
Freezer meal. Assemble it in a freezer-safe container, do not bake. Allow it to cool a bit before wrapping it tightly with plastic and again with aluminum foil. Label and freeze it for 3-4 months. Thaw overnight in the fridge before baking.
STORE. Keep any leftovers in an airtight container in the fridge for 3-4 days. Heat it up in the microwave when you’re ready to eat it.

Nutrition

Calories: 276kcal, Carbohydrates: 14g, Protein: 26g, Fat: 13g, Saturated Fat: 7g, Polyunsaturated Fat: 1g, Monounsaturated Fat: 4g, Trans Fat: 0.01g, Cholesterol: 84mg, Sodium: 847mg, Potassium: 406mg, Fiber: 2g, Sugar: 3g, Vitamin A: 698IU, Vitamin C: 6mg, Calcium: 263mg, Iron: 1mg

Nutrition information is automatically calculated, so should only be used as an approximation.

Additional Info

Course: Main Course
Cuisine: Mexican
Making this recipe? Tag us!
Share it with us on Instagram using the hashtag #lilluna, so we can see what you’re creating in the kitchen!

About Kristyn

My name is Kristyn and I’m the mom of SIX stinkin’ cute kids and the wife to my smokin’ hot hubby, Lo. My mom’s maiden name is Luna, and I’m one of the many crafty “Lil’ Lunas” in the fam. On this site I like to share all things creative - from recipes to home decor to gifts and home decor ideas. Welcome!

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Recipe Rating




32 Comments

  1. Cedar says:

    Is the rice supposed to be pre-cooked?

    1. Kristyn Merkley says:

      Yes, the rice is cooked first 🙂 Enjoy!!

  2. Olivia says:

    5 stars
    If you like mexican food casserole style, thiS is the one to try! It has everything you need in one. feeds many!

  3. Misty says:

    5 stars
    Mexican food is a must for me. It’s my all time favorite cuisine. This was very simple and fed a lot of people.

  4. Kristi says:

    5 stars
    Delicious! I always make your mexican rice when we Have MEXICAN food then freeze the LEFTOVERS specifically to make this casserole!

  5. Aimee Shugarman says:

    5 stars
    Total comfort food. And love how easy it was to make!

  6. Krissy Allori says:

    5 stars
    This will be a family favorite for sure!

  7. Beth Pierce says:

    5 stars
    I know what I will be having for dinner tonight! This looks amazing; so excited to give this a try!

  8. Kimberly says:

    5 stars
    This is so perfect for a quick and tasty weeknight meal!

  9. Kellie Hemmerly says:

    5 stars
    This casserole is so easy to make and is already being requested by the littles for an encore! Back on the weekly menu this week!!

  10. Joy says:

    5 stars
    This was amazing!! It had so much flavor & was very simple to make. We love Mexican food, so having it in a casserole form is a great idea! Perfect for feeding a crowd.