Pepperoni Pizza Grilled Cheese

This is a sponsored conversation written by me on behalf of Sara Lee® Bread. As always, all opinions are 100% my own.

Take your favorite grilled cheese sandwich and stuff it turn it into a pepperoni pizza! This fun twist on a classic is stuffed with mozzarella, pepperoni and sandwiched between two pieces of buttery garlic toast.

Pepperoni Pizza Grilled Cheese

Pizza Grilled Cheese

Grilled cheese sandwiches are a staple at our house, especially during winter and spring. They are so quick and easy to make! We’re always making them to go along with soup, or serving them with baked beans and fresh fruit. Since April is National Grilled Cheese Month (April 12th is National Grilled Cheese Day) I thought it would be fun to share a tasty twist on a classic. This version tastes just like pepperoni pizza stuffed between garlic bread and wow is it good- a family favorite! I mean, who doesn’t love pepperoni pizza?!

I used two slices of thick, soft Sara Lee®Artesano™ Bread – it’s the ORIGINAL artisan-style sliced bread. It happens to be free of high fructose corn syrup, artificial flavors and colors which is always a bonus in this mom’s book. We love using it for French toast too! It’s also available in Golden Wheat, which includes a touch of honey, olive oil and sea salt!

Sara Lee Artesano Baker Bread

How to make Pepperoni Pizza Grilled Cheese:

  1. Take one slice of Artesano Bread and put it into a hot skillet along with some butter.
  2. Add a slice of mozzarella cheese, followed by pepperoni and another slice of cheese. TIP: since the pepperoni doesn’t actually cook, you’ll want to place it onto a microwave-safe plate lined with a paper towel and cook it for about 20-25 seconds. This will also help release a lot of the grease. Dab it off and it’s ready to go.
  3. Place another piece of Artesano Bread on top, then cook and flip.
  4. Once the cheese looks melty, spread the garlic butter on and cook on both sides for an additional 30 seconds. Remove and enjoy!

Pizza Grilled Cheese

Pizza Grilled Cheese Sandwich recipe

Pepperoni Pizza Grilled Cheese Sandwich recipe

I’m all about making delicious, family-friendly recipes and this is one that we love. A few extra ingredients really take this from being a typical grilled cheese to being something you can’t stop eating! Every bite is full of melty cheese, pepperoni and of course, buttery garlic toast. YUM!

To celebrate National Grilled Cheese month, Sara Lee Bread is hosting a “Grilled Cheese Worth Celebrating Photo Sweepstakes”

  • You could win $1,000 OR a year supply of Sara Lee Artesano Bread
  • How to enter: post a photo on Instagram with the hashtags #ArtesanoBread and #Sweepstakes or enter via the form here>>>>


For more grilled cheese recipes, be sure to check out:

More Pizza Posts:

Pepperoni Pizza Grilled Cheese recipe

5 from 8 votes

Pepperoni Pizza Grilled CheeseTake your favorite grilled cheese sandwich and stuff it turn it into a pepperoni pizza! This fun twist on a classic is stuffed with mozzarella, pepperoni and sandwiched between two pieces of buttery garlic toast.

Course Main Course
Cuisine American
Prep Time 5 minutes
Cook Time 5 minutes
Total Time 10 minutes
Servings 2
Calories 625 kcal
Author on


  • 1 tbsp. unsalted butter
  • 4 slices Sara Lee® Artesano™ Bread
  • 4 slices mozzarella cheese, 1/8-inch thick
  • 18 slices pepperoni cooked in microwave for 20 seconds and grease dabbed off

For the garlic butter

  • 3 tbsp. unsalted butter
  • 1/4 tsp. fresh or dried parsley
  • 1/4 tsp. Italian seasoning
  • 1/4 tsp. garlic powder
  • 1/8 tsp. salt


  1. In a medium skillet set over medium-low heat, add the butter and melt. Place two pieces of toast side by side.

  2. To each slice of bread, add a slice of mozzarella, 9 pepperoni, and another slice of mozzarella. Place remaining slices of bread on top.

  3. Cook on each side for about 3 minutes or until the cheese is melty.

  4. Meanwhile, make the garlic butter. In a small microwave safe bowl, add the butter. Heat until melted. Stir in parsley, Italian seasoning, garlic powder, and salt. 

  5. Using a pastry brush, brush on both sides of grilled cheese. Cook on each side for 30 seconds. Remove, sprinkle with parmesan cheese and dip in your favorite marinara, if desired.

For more information about and recipes from Sara Lee Bread, be sure to head HERE. You can also find them on Facebook, Pinterest and Instagram. ENJOY!

This is a sponsored conversation written by me on behalf of Sara Lee Bread. The opinions and text are all mine.


Natalie Dicks

I’m the food photographer and blogger behind Life Made Simple. I’m passionate about creating from scratch family-friendly recipes ranging from healthy to decadent.

More by Natalie

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Recipe Rating



  2. 5 stars
    THis recipe is AMAZING!!!!!! I totally recommend it. The seasoned butter makes the bread taste like garlic bread, and it has the perfect amount of pepperoni. The step where it says to put the pepperoni in the microwave and then dab off the grease is ingenious. It makes it so that the grilled cheese doesn’t get greasy! I always toast both sides of my bread, just to get more of that mouth-watering garlic bread flavor and also so it gets the bread more crispy. I also usually cook the pepperoni in the microwave for 15 seconds instead of 20. That way it still retains some of its moisture and it doesn’t get all dried out. MAKE this recipe!!!!

  3. 5 stars
    I found this recipe before i had surgery so my sister came over and made it for Me. Yum yum! She did change up and started cooking them in the Oven. Melt the butter and spices in the microwaVe then brush it on the break. Make the sandwich place in a preheated 350 oven for 10-15 minutes. I flip it half way through. Also its good with italian sub sandwich meat. Thank you for this one!