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Cheesy Chicken Alfredo Bake is a simple twist on a family favorite! It’s an easy dinner, perfect any night of the week.

A twist on a classic Chicken Alfredo, this chicken alfredo casserole is just as cheesy and delicious. Serve it with soup or salad for a complete meal!

A close up of chicken alfredo casserole being scooped from a baking dish.
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casserole version of a classic

Who doesn’t love Pasta?! We make at least one pasta dish a week.

Our favorites include Spaghetti, Homemade Mac and Cheese, Creamy Penne Pasta – you name it!

We LOVE Fettuccine Alfredo and knew a casserole version with chicken would be just as good. We were right… this recipe is a family favorite and is on the monthly rotation because it’s loved by all.

Penne pasta for Chicken Alfredo casserole recipe.

How to Make

OPTIONAL MARINADE. If time allows, marinate the chicken. Add chicken and Italian dressing to a bag. Let sit overnight or even a few hours to make the chicken tender and full of flavor.

PASTA. Cook pasta as directed. Drain and set aside.

While pasta is cooking, heat 1-2 TB of oil in a skillet on medium heat.

CHICKEN. Slice your marinated chicken in half so they are thinner pieces. This will help them cook through evenly.

  • In a bowl, mix salt, pepper, thyme, and poultry seasoning. Rub it on all sides of your chicken breasts.
  • Add chicken to hot oil and cook on both sides until done (about 15-20 minutes).
  • Remove to a plate to let cool.
Wooden spoon filled with alfredo sauce over a saucepan of alfredo sauce.

Continued…

SAUCE. While the chicken is cooling, preheat your oven to 350°F and start on your sauce. In a separate large skillet melt the butter; add garlic and cook for 1-2 minutes.

  • Using a wire whisk, mix in flour and stir until bubbly.
  • Mix in half & half and milk (you can also sub these two for heavy cream), and stir to combine. Bring to a boil and then reduce to low heat and simmer for 5 minutes.
  • With your whisk, mix in 1½ cups of cheese. Cook an additional 5 minutes until the sauce starts to thicken.
  • Remove sauce from heat.

ASSEMBLE. Cut your cooked chicken into bite-size pieces and add to a large bowl. Add the pasta to your bowl and then the sauce. Mix everything to combine.

BAKE. Spray a 9×13 baking dish with nonstick spray. Add the pasta mixture to the pan and sprinkle with an additional 1½ cups of cheese.

Sprinkle with pepper and bake for 30 minutes or until bubbly and golden brown. Garnish the dish with chopped parsley, if desired.

A white mixing bowl full of shredded chicken.

Recipe Tips

Pasta. Alfredo sauce is often served over fettuccine noodles, but we chose to use penne noodles for this baked dish. Other pasta choices include mini penne or rigatoni.

Veggies. Add broccoli, spinach, peas, corn, bell peppers, or mushrooms.

Chicken. Use leftover chicken or rotisserie chicken to save time. Make chicken alfredo pasta bake without chicken or substitute the chicken with cooked sausage. Mix in shrimp or add crumbled bacon on top. 

Kraft 5 Italian Cheese Blend contains mozzarella cheese, provolone cheese, parmesan cheese, asiago cheese, and romano cheese. Shred your own cheese blend using these cheeses.

Baked chicken Alfredo casserole in a baking dish ready for cooking.

What to serve with Baked Chicken Alfredo

There are so many sides and bread that go great with this chicken alfredo casserole. Here are some of our favorites:

Storing Info

Make ahead of time. Prepare as directed, cover, and place in the fridge. We typically do this the night before or the morning of, but it can be stored up to 24 hours before baking.

STORE leftovers in an airtight container(s) in the fridge for 3-4 days.

FREEZE. Allow the ingredients to cool and then wrap the dish with plastic wrap and again with aluminum foil. If done properly, it will keep for up to 2-3 months in the freezer.

Reheat. The best way to reheat a large amount is in the oven or on the stovetop. Reheat slowly over low heat and add extra milk to help smooth out the texture.

If you are in a hurry, or on the go, reheat smaller portions in the microwave. 

Scooping chicken alfredo bake from a baking dish.

Recipe FAQ

What is the difference between chicken alfredo and chicken fettuccine?

Chicken alfredo is made with a creamy white sauce, whereas chicken fettuccine can be made with any kind of sauce.

What goes best with chicken alfredo casserole?

We love to serve this casserole with Garlic Knots, Roasted Vegetables, or any one of our green salads!

Do I have to use penne pasta for this recipe?

Nope! You can use any type of pasta that pairs well with rich and creamy sauces. Linguine or rigatoni would be great in this dish!

For more cheesy pasta recipes, check out:

4.97 from 104 votes

Chicken Alfredo Bake Recipe

By: Lil’ Luna
Cheesy Chicken Alfredo Casserole is a simple twist on a family favorite! It's an easy dinner, perfect any night of the week.
Servings: 8 people
Prep: 35 minutes
Cook: 30 minutes
Total: 1 hour 5 minutes

Ingredients 

  • 12 oz. pkg penne pasta
  • 3 boneless skinless chicken breasts marinated in Italian dressing if desired
  • vegetable oil
  • 1/4 tsp thyme
  • 1/4 tsp poultry seasoning
  • salt and pepper to taste
  • 2 TB olive oil
  • 1/2 c butter
  • 2 tsp minced garlic
  • 4 TB all-purpose flour
  • 3 c half and half
  • 3 c milk
  • 3 c Kraft Italian Five Cheese Blend divided
  • Italian Seasoning, garnish

Instructions 

  • If time allows, always try to marinate your chicken. Throw them in a bag of Italian dressing and let sit overnight or even a few hours will help your chicken to be tender and full of flavor.
  • Cook pasta as directed. Drain and set aside.
  • While pasta is cooking, heat 1 – 2 TB of oil in a skillet on medium heat.
  • Slice your marinated chicken in half so they are thinner pieces. This will help them cook through evenly.
  • In a bowl mix salt, pepper, thyme and poultry seasoning and rub it on all sides of your chicken breasts. Add chicken to hot oil and cook on both sides until done (about 15-20 minutes). Remove to a plate to let cool.
  • While the chicken is cooling, preheat your oven to 350°F and start on your sauce. In a separate large skillet melt the butter; add garlic and cook for 1 – 2 minutes.
  • Using a wire whisk, mix in flour and stir until bubbly. Mix in half & half and milk, stir to combine. Bring to a boil and then reduce to low heat and simmer for 5 minutes.
  • With your whisk, mix in 1½ cup of cheese. Cook an additional 5 minutes until sauce starts to thicken. Remove sauce from heat.
  • Cut your cooked chicken into bite size pieces and add to a large bowl. Add the pasta to your bowl and then the sauce. Mix everything to combine.
  • Spray a 9×13 baking pan with non stick spray. Add the pasta mixture to the pan and sprinkle with an additional 1½ cup of cheese.
  • Sprinkle with pepper and bake for 30 minutes or until bubbly and golden brown.

Video

Nutrition

Calories: 588kcal, Carbohydrates: 11g, Protein: 34g, Fat: 44g, Saturated Fat: 25g, Cholesterol: 171mg, Sodium: 539mg, Potassium: 593mg, Sugar: 5g, Vitamin A: 1275IU, Vitamin C: 2.1mg, Calcium: 513mg, Iron: 0.9mg

Nutrition information is automatically calculated, so should only be used as an approximation.

About Kristyn

My name is Kristyn and I’m the mom of SIX stinkin’ cute kids and the wife to my smokin’ hot hubby, Lo. My mom’s maiden name is Luna, and I’m one of the many crafty “Lil’ Lunas” in the fam. On this site I like to share all things creative - from recipes to home decor to gifts and home decor ideas. Welcome!

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4.97 from 104 votes (72 ratings without comment)

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Recipe Rating




150 Comments

  1. Jessica says:

    5 stars
    Really good of course i added a little splash of spanish seasoning to my chicken but everythjng else was followed exact.

    1. Kristyn Merkley says:

      Perfect! Thank you for letting me know!

  2. Danea Bullock says:

    5 stars
    What a great recipe and it turned out perfect.. My family love it. The leftovers were even better the next day. My daugter Is already asking when can i make it again!

    1. Kristyn Merkley says:

      Yes, leftovers are better the next day! I am so happy to hear your family loved it! Thank you!

  3. Lanae says:

    5 stars
    Amazing

    1. Kristyn Merkley says:

      Thank you so much!! I agree 🙂

  4. michelle kropp II says:

    your chicken alfredo recipe sounds so good! That’s a go to for my husband and me, however, we’re gone alot and I was hoping you could share how I might be able to do this in my crock pot. The time and any other suggestions. Thank you!

    1. Kristyn Merkley says:

      I have not tried it in the crock pot, but I am sure it would work. I would think low for 3-4 hrs setting.

  5. Jill says:

    I’m taking a meal to a family and this would be perfect! Do you know if it would be freezeable? Sorry if you mentioned this and I missed that part!

    1. Kristyn Merkley says:

      Yes, totally can. Thank you for sharing this 🙂

  6. Stephanie, One Caring Mom says:

    This looks so good. I love anything with alfredo sauce so I know this will be amazing. Thanks for sharing!!

    1. Kristyn Merkley says:

      I do too!! Hope you like it 🙂 Thanks for stopping by!

  7. Erica B says:

    Hello, looking forward to trying this out!! I am going to try and make it tonight, refirgerate it and put in crock pot tomorrow. I know from other alfredo sauces, the butter seperates but from the comments about left overs, i am guessing this is not the case here?
    I am salavating just looking at the pictures!! 🙂

    1. Kristyn Merkley says:

      It’s a good one! Hope you like it! Not really, but we hardly ever have left overs. Enjoy!

  8. Dense says:

    Can I just use leftover baked chicken or rotisserie chicken? if so, what quantity?

    1. Kristyn Merkley says:

      Of course 🙂 I’d use like 2 cups. You could always add more or less, depending on how much chicken you like. Enjoy!

  9. Cindy says:

    There are 2 different types of Kraft Italian 5 Cheese. One says with Philadelphia Cream Cheese, the other doesn’t. the one you mentioned in the recipe does not say with Philadelphia but down in the comments you say use the one with cream cheese?

    1. Kristyn Merkley says:

      The one with cream cheese 🙂 Hope you like it!

    2. jacky says:

      what is half and half

      1. Lil'Luna Team says:

        Half-and-half is simply an equal-parts combination of milk and cream. It is half whole milk, half heavy cream. You can find it in the grocery store by the milk/cream/dairy products in the refrigerators. You can also create it yourself by combining 1/2 cup whole milk and 1/2 cup heavy cream.

  10. Allie says:

    4 stars
    Would it be okay to use less half and half? I only have 2 cups. Also im wondering why so much when theres already 3 cups of milk? Just seems like a lot

    1. Kristyn Merkley says:

      You could 🙂 It makes it so creamy.