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No dish is left behind with the delicious mash-up of this Thanksgiving leftover casserole – the best way to enjoy Turkey Day leftovers!

Thanksgiving leftover casserole close up in a baking dish.
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Leftover Problems Solved!

We have the perfect way to use up all of that leftover Turkey with this Thanksgiving leftover casserole!

We LOVE stuffing our faces with friends and family, but we inevitably have Thanksgiving leftovers. Sometimes it’s hard to use them all up without letting them go to waste – this casserole is the perfect dinner solution!

This dish is a layered combination of Turkey, Stuffing, and (of course) Mashed Potatoes! Hard to believe, but it’s just as good the second time around, if not better.

WHY WE LOVE IT:

  • No-waste cooking. Turn your Thanksgiving leftovers into a delicious and satisfying meal.
  • No leftovers? No problem! We’ve included steps to make this casserole from scratch as well!
  • Use what you have. You can tailor the casserole to your preferences by adding or removing ingredients depending on your leftovers!
Russet potatoes on a wooden table.

Ingredients

Use Thanksgiving leftovers or make the different layers from scratch

  • 6 medium russet potatoes, peeled and cut into chunks – or use leftover Mashed Potatoes

Stuffing

  • 6 cups unseasoned stuffing cubes
  • 1 teaspoon poultry seasoning
  • ¼ teaspoon rubbed sage
  • 1 cup chicken broth – or chicken stock

Turkey

  • 4 cups cooked turkey, cubed – Use leftover Roast Turkey or purchase thick slices from the deli to cube.

Casserole Sauce

  • 2 (10.75-ounce) cans condensed cream of chicken soup, undiluted – or Cream of Mushroom Soup or Cream Soup Substitute
  • 1 teaspoon garlic powder
  • ¾ cup sour cream, divided – or plain or Greek yogurt
  • 4 ounces cream cheese softened
  • ½ teaspoon black pepper
  • ¼ teaspoon salt
  • 1-1½ cups shredded cheddar cheese
  • veggies like peas, green beans, or corn

How to Make Thanksgiving Leftover Casserole

  1. PREP. Preheat the oven to 350°F.
    • Cube 6 potatoes and place in a large pot and cover with water. Bring to a boil, reduce heat, and cook for an additional 12-15 minutes (or until tender).
  2. STUFFING. While potatoes are cooking, combine 6 cups stuffing cubes, 1 teaspoon poultry seasoning, and ¼ teaspoon sage in a large bowl. Stir in 1 cup broth and pour into a greased 9×13 baking dish.
  3. TURKEY. In another large bowl, combine 4 cups cubed turkey, 2 cans cream of chicken soup,1 teaspoon garlic powder, and ¼ cup sour cream. Spoon over the stuffing mixture.
  4. POTATOES. Drain potatoes and mash in a large bowl. Beat in 4 ounces cream cheese, ½ teaspoon pepper, ¼ teaspoon salt, and remaining ½ cup sour cream, then spread over turkey mixture.
  5. BAKE. Sprinkle with cheese and bake for 30-35 minutes.
Close up image of Thanksgiving leftover casserole in glass baking dish.

Complete The Meal

Side Dishes

Desserts

More Casseroles

Collections

5 from 10 votes

Thanksgiving Leftover Casserole

By: Lil’ Luna
No dish is left behind with the delicious mash-up of this Thanksgiving leftover casserole – the best way to enjoy Turkey Day leftovers!
Servings: 9
Prep: 15 minutes
Cook: 45 minutes
Total: 1 hour

Ingredients 

Mashed Potatoes

  • 6 medium potatoes, peeled and cut into chunks

Stuffing

  • 6 cups stuffing cubes, unseasoned
  • 1 teaspoon poultry seasoning
  • ¼ teaspoon rubbed sage
  • 1 cup chicken broth

Turkey

  • 4 cups cooked turkey, cubed

Casserole Sauce

  • 2 (10.75-ounce) cans condensed cream of chicken soup, undiluted
  • 1 teaspoon garlic powder
  • ¾ cup sour cream, divided
  • 4 ounces cream cheese, softened
  • ½ teaspoon pepper
  • ¼ teaspoon salt
  • 1-1½ cups cheddar cheese, shredded

Instructions 

  • Preheat the oven to 350°F.
  • Place potatoes in a large pot and cover with water. Bring to a boil, reduce heat, and cook for an additional 12-15 minutes (or until tender).
  • While potatoes are cooking, combine stuffing cubes, poultry seasoning, and sage in a large bowl. Stir in broth and pour into a greased 9×13 baking dish.
  • In another large bowl, combine the turkey, soup, garlic powder, and ¼ cup sour cream. Spoon over the stuffing mixture.
  • Drain potatoes and mash in a large bowl. Beat in the cream cheese, pepper, salt, and remaining sour cream, and spread over the turkey mixture.
  • Sprinkle with cheese and bake for 30-35 minutes. ENJOY!

Notes

Using leftovers. You can use leftovers from Thanksgiving dinner for each layer, or follow the recipe to make the different layers from scratch.
Store leftover casserole in an airtight container(s) in the fridge for about 3 days or in the freezer for up to 1 month. 

Nutrition

Calories: 519kcal, Carbohydrates: 36g, Protein: 21g, Fat: 32g, Saturated Fat: 13g, Cholesterol: 81mg, Sodium: 1497mg, Potassium: 319mg, Fiber: 4g, Sugar: 4g, Vitamin A: 1049IU, Vitamin C: 2mg, Calcium: 230mg, Iron: 3mg

Nutrition information is automatically calculated, so should only be used as an approximation.

Recipe FAQ

How to store?

Store leftover casserole in an airtight container(s) in the fridge for about 3 days or in the freezer for up to 1 month. 

Adapted from Taste of Home.

About Kristyn

My name is Kristyn and I’m the mom of SIX stinkin’ cute kids and the wife to my smokin’ hot hubby, Lo. My mom’s maiden name is Luna, and I’m one of the many crafty “Lil’ Lunas” in the fam. On this site I like to share all things creative - from recipes to home decor to gifts and home decor ideas. Welcome!

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5 from 10 votes (6 ratings without comment)

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Recipe Rating




7 Comments

  1. Sandra L says:

    5 stars
    This turned out amazing! I used leftover stuffing, so that made it easier. Also, I used one can of cream of chicken soup and one can of cream of broccoli soup (what I had in hand). The potatoes were creamy and delicious. I highly recommend this recipe.

    1. LilLunaTeam says:

      I’m so glad you enjoyed the recipe! Thanks for sharing!

  2. Shayla says:

    5 stars
    This is one of our favorite recipes-perfect for left overs that doesn’t taste like a left over. Yum!!

  3. Amy says:

    5 stars
    Can always appreciate a new way to use up those never-ending thanksgiving leftovers!

  4. Jackie says:

    Whats the butter for?

  5. Ana Maria says:

    5 stars
    Super creamy and good!

  6. Laura says:

    I’m confused, why is the video in the middle of this post for another recipe?